Businesses in Wales hit by coronavirus will be offered £140m in grants, Economy Minister Ken Skates has said.
Nearly two-thirds of Wales' population will be under lockdown when new restrictions are imposed at 18:00 BST.
Neath Port Talbot (NPT), Torfaen and Vale of Glamorgan will join eight other areas in lockdown, affecting almost two million people in total.
The country's two biggest cities – Cardiff and Swansea – had restrictions applied on Sunday evening.
The new rules mean no travel outside council boundaries other than for work, education or medical emergencies, with no indoor mixing allowed and no alcohol sales after 22:00.
Mr Skates said two new separate schemes would help businesses in those affected areas, similar to those announced in England.
"This £140m will no doubt make the difference between business survival and business death for thousands of enterprises," he said.
"It will make the difference between employment and unemployment for thousands more workers."
The first scheme, worth £60m, will be targeted at areas hit by this month's rolling announcements of local lockdowns.
It will offer grants of between £1,000 and £1,500 to businesses with a rateable value under £50,000 that can demonstrate a material impact because of the new restrictions.
A second scheme, worth £80m, will provide larger grants to firms across Wales that can demonstrate plans for post-coronavirus recovery. Of that money, £20m has been earmarked for tourism and hospitality businesses.
Mr Skates also said there was a "significant gap" in unemployment between Wales and the rest of the UK.
Despite predictions Wales would be "worst hit", the rate of unemployment in Wales from May to July was 3.1%, compared to 4.1% for the whole of the UK, latest figures show.
Mr Skates said that difference was because Wales had "the most generous package" of support for businesses and was the "equivalent of 15,000 jobs saved".
Welcoming the UK government's new Job Support Scheme, he added that "direct interventions" by the Welsh Government had secured more than 100,000 jobs.
The new measures will mean half of Wales' 22 local authorities will be under lockdowns.
NPT council leader Rob Jones said the area was seeing rising case rates.
"We need the help of everyone across Neath Port Talbot to prevent the increasing spread of coronavirus and to bring the infection rates back down."
But wedding planner Gail Windley told BBC Radio Wales Breakfast it was an "incredibly frustrating" time for everyone involved in weddings.
"The rug is being pulled from under your feet constantly," said Ms Windley, who lives in Neath Port Talbot.
She said one bride she was working with was "very stressed" and would be "glad to get it over with".
"A wedding is a milestone in your life – that's how your ancestors will trace you back – so it's heart-breaking to be involved in that and see it."
Torfaen council leader Anthony Hunt said the local lockdown strategy was working in neighbouring Caerphilly and Newport, where he said numbers had "dropped dramatically".
A businesswoman in Cwmbran said she was hoping the local lockdown would not affect her too much.
"The majority of customers are local to Torfaen and I do online as well, so I am hoping, fingers crossed, that it's not too bad," said Rosa Newton, who owns an antiques and vintage shop in Cwmbran.
Ms Newton said she felt "better prepared" for tighter restrictions this time than she did for the national lockdown in March.
"Within the shop, it's all face masks, hand sanitiser – I feel safe and I feel my customers are safe," she said.
"I will switch to more online shopping. We have to just switch and do what we can as a business to keep going really."
Liam Lazarus and his partner Bethan run a cafe in Swansea.
"It's crazy – it feels like the goal posts are changing in the industry all the time," he said.
"We were getting into a nice rhythm, so now this is happening we are taking a step back."
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